Aim of present study was to formulate, optimize and evaluate mouth dissolving tablet of palonosetron hydrochloride.\nTablet was formulated by direct compression method by using different super disintegrating agents like crospovidone,\ncroscarmellose sodium and sodium starch glycollate. For optimization of final formulation 32 factorial design was applied. The\nconcentration of microcrystalline cellulose and crospovidone were selected as an independent variable and disintegration time,\nwetting time and in-vitro drug release as dependent variable. Formulations were evaluated for parameters like hardness,\ndisintegration time, in-vitro drug release study, wetting time, drug content and drug excipients compatibility study. Study\ndemonstrates that the release profile depends on the concentration of crospovidone. The optimized formula obtained from\ndifferent factorial batches of experimental design matches with the predicted value from design expert software. The optimized\nbatch was evaluated for the parameters like hardness, disintegration time, in-vitro drug release study, wetting time and drug\ncontent. The final formulation was stable after 3 months stability study as per ICH guideline conditions. The studies indicate that\nthe formulation was having less disintegration time as well as fast in-vitro drug release. Crospovidone is the key ingredient\nwhich significantly affects disintegration time as well as fast drug release effect. Fast dissolving formulation of palonosetrone\nHCl can be successfully formulated and used for patients who refuse to swallow conventional tablets such as pediatric, geriatric\nand psychiatric patients.
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